Dengue virus and the host innate immune response
نویسندگان
چکیده
منابع مشابه
Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response
Autophagy is a catabolic process that is important for maintaining cellular homeostasis. This pathway in hepatocytes is stimulated and controlled by the hepatitis C virus (HCV)-upon infection-to promote its own replication. HCV induces autophagy indirectly and directly through different mechanisms and temporally controls the autophagic flux. This enables the virus to maximize its replication an...
متن کاملInterference of Host Innate Immune Response by Hepatitis E Virus
Title of Document: INTERFERENCE OF HOST INNATE IMMUNE RESPONSE BY HEPATITIS E
متن کاملDengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses.
With no antiviral drugs or widely available vaccines, Dengue virus (DENV) constitutes a public health concern. DENV replicates at ER-derived cytoplasmic structures that include substructures called convoluted membranes (CMs); however, the purpose of these membrane alterations remains unclear. We determine that DENV nonstructural protein (NS)4B, a promising drug target with unknown function, ass...
متن کاملExtracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response
The innate immune system plays a crucial role in controlling viral infection. Pattern recognition receptors (PRRs), such as Toll-like receptors and RIG-I-like receptors, sense viral components called pathogen-associated molecular patterns (PAMPs) and trigger signals to induce innate immune responses. Extracellular vesicles (EVs), including exosomes and microvesicles, deliver functional RNA and ...
متن کاملGP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation
Hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases and hepatocellular carcinoma (HCC) and Golgi protein 73 (GP73) is a serum biomarker for liver diseases and HCC. However, the mechanism underlying GP73 regulates HCV infection is largely unknown. Here, we revealed that GP73 acts as a novel negative regulator of host innate immunity to facilitate HCV infection. GP73 ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Emerging Microbes & Infections
سال: 2018
ISSN: 2222-1751
DOI: 10.1038/s41426-018-0168-0